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Centre for Preclinical Testing of Active Substances / Laboratory for Cell and Molecular Biology (Center)
Faculty of Natural Sciences and Mathematics Kragujevac
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Centre for Preclinical Testing of Active Substances – CPCTAS is a separate organizational unit of the Faculty of Science that acts in accordance with its Statute. Centre was founded in 2008, at the beginning of realization of the three-year project EU: FP7 – Capacities,  Research Potential, CENTRE FOR PRE-CLINICAL TESTING OF ACTIVE SUBSTANCES (CPCTAS, GA 206809). In a relatively short time, the Centre has managed to increase its material base and technical equipment to reinforce through personnel and structural changes and to gain experience and references by a number of papers issued. Laboratory for Cell and Molecular Biology is a central part in charge for coordinating activities of Centre for Preclinical Testing of Active Substances and, accordingly, of organization and activities subject to accreditation of Laboratory in accordance with SRPS ISO/IEC 17025:2006.


•     Chemical synthesis, purification and extraction of bioactive substances, microbiological, cell and molecular, immunological and pharmacological preclinical testing of active substances of wide span of action, scientific research work that connects basic research and clinic, as well as provision of services to the third party  
•     Testing the significance of physiological, genetic, molecular-biological and tumour markers in the assessment of effects of active substances and prediction of pathological state of people 
•     Defining the mechanisms of active substances activity in biological systems with clear feedback information for chemical synthesis of new variations of active substances with improved characteristic, as well as defined output for distribution, clinical testing and application of tested active substances  

Name email Host institution
true Marković Snežana smarkovic@kg.ac.rs Faculty of Natural Sciences and Mathematics Kragujevac
Ćurčić Milena Faculty of Natural Sciences and Mathematics Kragujevac
Cvetković Danijela Faculty of Natural Sciences and Mathematics Kragujevac
Obradović Ana Faculty of Natural Sciences and Mathematics Kragujevac
Šeklić Dragana Faculty of Natural Sciences and Mathematics Kragujevac
Živanović Marko Faculty of Natural Sciences and Mathematics Kragujevac
Žižić Jovana Faculty of Natural Sciences and Mathematics Kragujevac

•     The Centre was legally established and technically equipped within CPCTAS project: maintenance of existing technical resources as well as purchase of new equipment within PIBAS project  
•     The Centre employs seven young researchers (doctoral students); all newly employed researchers passed two-month education in related laboratories in EU  
•     Laboratory engages 6 young researchers (students of doctoral studies) through PIBAS project  
•     Since its establishment, the Laboratory has been performing scientific – research and educational activities; currently elaboration of 6 doctoral dissertations is in progress  
•     For two-year period (2011-2012), the Laboratory performed the testing of biological activities of chemically synthetized substances and extracts, i.e. isolated pure substances from plant material (over 120 samples) 
•     Technical equipment and educated personnel allow the Laboratory to develop within scientific – research and educational work, but also an exit to the market and cooperation with the clinic and pharmaceutical companies  

1.    Stanković MS, Ćurčić MG, Žižić JB, Topuzović MD, Solujić SR, Marković SD. Teucrium Plant Species as Natural Sources of Novel Anticancer Compounds: Antiproliferative, Proapoptotic and Antioxidant Properties. Int J Mol Sci 2011, 12: 4190-4205;
    doi:10.3390/ijms12074190 ISSN: 1661-6596 M21
2.    Trišović N, Božić B, Obradović A, Stefanović O, Marković S, Čomić Lj, Božić B, Ušćumlić G. Structure-activity relationships of 3-substituted-5,5-diphenylhydantoins as potential antiproliferative and antimicrobial agents. J Serb Chem Soc 2011, 76: 1597-1606.
    ISSN: 0352-5139 M23
3.    Ćurčić MG, Stanković MS, Radojević ID, Stefanović OD, Čomić LjR, Topuzović MD, Đačić DS, Marković SD. Biological effects, total phenolic content and flavonoid concentrations of fragrant yellow onion (Allium flavum L.). Med Chem 2012, 8: 46-51. ISSN:
    1573-4064 M22
4.    Ćurčić MG, Stanković MS, Mrkalić EM, Matović ZD, Banković DD, Cvetković DM, Đačić DS, Marković SD. Antiproliferative and Proapoptotic Activities of Methanolic Extracts from Ligustrum vulgare L. as an Individual Treatment and in Combination with
    Palladium Complex. Int J Mol Sci 2012, 13(2): 2521-2534. ISSN: 1661-6596 M21
5.    Šmit B, Pavlović RZ, Radosavljević-Mihajlović A, Došen A, Ćurčić MG, Šeklić DS, Živanović MN. Synthesis, characterization and cytotoxicity of palladium(II) complex of 3-[(2-hydroxy-benzylidene)-amino]-2-thioxo-imidazolidin-4-one J Serb Chem Soc 2013, 78(2): 217-227. doi: 10.2298/JSC120725154S). M23
6.    Žižić JB, Vuković NL, Jadranin MB, Anđelković BD, Tešević VV, Kacaniova MM, Sukdolak SB, Marković SD. Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line. J Sci Food Agr 2013. DOI: 10.1002/jsfa.6132. ISSN: 0022-5142 M21


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Radoja Domanovića 12, 34000 Kragujevac, Srbija
+381 34 336 223 lok. 300
(FOS1) Natural sciences
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Molecular biology Cell biology Colon and breast cancer cell lines MTT Cytotoxicity Apoptosis Oxidative stress NBT Redox status GSH Multiplex PCR Immunofluorescence Bioactive substances Pre-clinical research CPCTAS / PIBAS LCMB